| http://purl.uniprot.org/citations/19955429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19955429 | http://www.w3.org/2000/01/rdf-schema#comment | "Pain associated with inflammation involves prostaglandins synthesized from arachidonic acid (AA) through cyclooxygenase-2 (COX-2) pathways while thromboxane A(2) formed by platelets from AA via cyclooxygenase-1 (COX-1) mediates thrombosis. COX-1 and COX-2 are both targets of nonselective nonsteroidal antiinflammatory drugs (nsNSAIDs) including aspirin whereas COX-2 activity is preferentially blocked by COX-2 inhibitors called coxibs. COXs are homodimers composed of identical subunits, but we have shown that only one subunit is active at a time during catalysis; moreover, many nsNSAIDS bind to a single subunit of a COX dimer to inhibit the COX activity of the entire dimer. Here, we report the surprising observation that celecoxib and other coxibs bind tightly to a subunit of COX-1. Although celecoxib binding to one monomer of COX-1 does not affect the normal catalytic processing of AA by the second, partner subunit, celecoxib does interfere with the inhibition of COX-1 by aspirin in vitro. X-ray crystallographic results obtained with a celecoxib/COX-1 complex show how celecoxib can bind to one of the two available COX sites of the COX-1 dimer. Finally, we find that administration of celecoxib to dogs interferes with the ability of a low dose of aspirin to inhibit AA-induced ex vivo platelet aggregation. COX-2 inhibitors such as celecoxib are widely used for pain relief. Because coxibs exhibit cardiovascular side effects, they are often prescribed in combination with low-dose aspirin to prevent thrombosis. Our studies predict that the cardioprotective effect of low-dose aspirin on COX-1 may be blunted when taken with coxibs."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0909765106"xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Smith W.L."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Yuan C."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Trievel R.C."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Sidhu R.S."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Sharma N.P."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Lucchesi B.R."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Rimon G."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Frieler R.A."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/author | "Lauver D.A."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/pages | "28-33"xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/title | "Coxibs interfere with the action of aspirin by binding tightly to one monomer of cyclooxygenase-1."xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/19955429 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19955429 |
| http://purl.uniprot.org/citations/19955429 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19955429 |
| http://purl.uniprot.org/uniprot/#_P05979-mappedCitation-19955429 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19955429 |
| http://purl.uniprot.org/uniprot/P05979 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19955429 |