| http://purl.uniprot.org/citations/19955433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19955433 | http://www.w3.org/2000/01/rdf-schema#comment | "Astrocytes and one of their products, IL-6, not only support neurons but also mediate inflammation in the brain. Retinoid-related orphan receptor-alpha (RORalpha) transcription factor has related roles, being neuro-protective and, in peripheral tissues, anti-inflammatory. We examined the relation of ROR(alpha) to astrocytes and IL-6 using normal and ROR(alpha) loss-of-function mutant mice. We have shown ROR(alpha) expression in astrocytes and its up-regulation by pro-inflammatory cytokines. We have also demonstrated that ROR(alpha) directly trans-activates the Il-6 gene. We suggest that this direct control is necessary to maintain IL-6 basal level in the brain and may be a link between the neuro-supportive roles of ROR(alpha), IL-6, and astrocytes. Furthermore, after inflammatory stimulation, the absence of ROR(alpha) results in excessive IL-6 up-regulation, indicating that ROR(alpha) exerts an indirect repression probably via the inhibition of the NF-kappaB signaling. Thus, our findings indicate that ROR(alpha) is a pluripotent molecular player in constitutive and adaptive astrocyte physiology."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0911782106"xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Trembleau A."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Mariani J."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Jolly S."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Rogard M."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Jarvis C."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Vernet-der Garabedian B."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Blondeau J.P."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Journiac N."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/author | "Gautheron V."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/pages | "21365-21370"xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/title | "The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes."xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19955433 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19955433 |
| http://purl.uniprot.org/citations/19955433 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19955433 |
| http://purl.uniprot.org/uniprot/P08505#attribution-39F48F2E0993F0C77B393C93E56F52AF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19955433 |
| http://purl.uniprot.org/uniprot/P20393#attribution-39F48F2E0993F0C77B393C93E56F52AF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19955433 |
| http://purl.uniprot.org/uniprot/Q3UV55#attribution-1DC62DB37050A4339EB0EDA78DAE67D0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19955433 |
| http://purl.uniprot.org/uniprot/P35398#attribution-39F48F2E0993F0C77B393C93E56F52AF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19955433 |
| http://purl.uniprot.org/uniprot/P51448#attribution-1DC62DB37050A4339EB0EDA78DAE67D0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19955433 |
| http://purl.uniprot.org/uniprot/P51448#attribution-39F48F2E0993F0C77B393C93E56F52AF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19955433 |