| http://purl.uniprot.org/citations/19955659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19955659 | http://www.w3.org/2000/01/rdf-schema#comment | "Thymic graft-versus-host disease (tGVHD) can contribute to profound T cell deficiency and repertoire restriction after allogeneic BM transplantation (allo-BMT). However, the cellular mechanisms of tGVHD and interactions between donor alloreactive T cells and thymic tissues remain poorly defined. Using clinically relevant murine allo-BMT models, we show here that even minimal numbers of donor alloreactive T cells, which caused mild nonlethal systemic graft-versus-host disease, were sufficient to damage the thymus, delay T lineage reconstitution, and compromise donor peripheral T cell function. Furthermore, to mediate tGVHD, donor alloreactive T cells required trafficking molecules, including CCR9, L selectin, P selectin glycoprotein ligand-1, the integrin subunits alphaE and beta7, CCR2, and CXCR3, and costimulatory/inhibitory molecules, including Ox40 and carcinoembryonic antigen-associated cell adhesion molecule 1. We found that radiation in BMT conditioning regimens upregulated expression of the death receptors Fas and death receptor 5 (DR5) on thymic stromal cells (especially epithelium), while decreasing expression of the antiapoptotic regulator cellular caspase-8-like inhibitory protein. Donor alloreactive T cells used the cognate proteins FasL and TNF-related apoptosis-inducing ligand (TRAIL) (but not TNF or perforin) to mediate tGVHD, thereby damaging thymic stromal cells, cytoarchitecture, and function. Strategies that interfere with Fas/FasL and TRAIL/DR5 interactions may therefore represent a means to attenuate tGVHD and improve T cell reconstitution in allo-BMT recipients."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci39395"xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Ghosh A."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Tsai J."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Lu S.X."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Beauchemin N."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Tran H."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Suh D."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Palomba L."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Rao U."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Sempowski G.D."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Goldberg G.L."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Smith O.M."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "King C.G."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Merghoub T."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "van den Brink M.R."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Holland A.M."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Na I.K."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Penack O."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Hirschhorn-Cymerman D."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Jenq R.R."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Ventevogel M."xsd:string |
| http://purl.uniprot.org/citations/19955659 | http://purl.uniprot.org/core/author | "Yim N.L."xsd:string |