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http://purl.uniprot.org/citations/1995638http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1995638http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1995638http://www.w3.org/2000/01/rdf-schema#comment"The cDNA and gene for mouse mast cell protease-6 (MMCP-6) have been sequenced and show MMCP-6 to be translated as a prepro-enzyme with a 21-amino acid hydrophobic leader peptide, a 10-amino acid activation peptide, and a 245-amino acid mature enzyme. The mature form of the enzyme has 73% amino acid sequence identity with human and dog mast cell tryptases. The MMCP-6 gene includes 6 exons, with a total span of 1.8 kilobases. A 208-base pair intron was defined which separates the 5'-untranslated sequence of MMCP-6 from the translation initiation codon, thereby presenting a gene organization which distinguishes tryptic serine proteases from chymotryptic serine proteases of the mast cell secretory granule. By RNA blot analysis with a gene-specific probe, MMCP-6 has a unique subclass distribution in being transcribed in mouse connective tissue mast cells but undetectable in mucosal mast cells. MMCP-6 is the first serine protease of any class to be shown to be significantly transcribed in progenitor, bone marrow-derived mast cells, which can reconstitute both mucosal mast cell and connective tissue mast cell populations in mast cell-deficient mice."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(19)67871-3"xsd:string
http://purl.uniprot.org/citations/1995638http://purl.org/dc/terms/identifier"doi:10.1016/s0021-9258(19)67871-3"xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/author"Austen K.F."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/author"Austen K.F."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/author"Gurley D.S."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/author"Gurley D.S."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/author"Reynolds D.S."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/author"Reynolds D.S."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/author"Serafin W.E."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/author"Serafin W.E."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/name"J. Biol. Chem."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/pages"3847-3853"xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/pages"3847-3853"xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/title"Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells and mast cells of the connective tissue subclass."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/title"Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells and mast cells of the connective tissue subclass."xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/volume"266"xsd:string
http://purl.uniprot.org/citations/1995638http://purl.uniprot.org/core/volume"266"xsd:string
http://purl.uniprot.org/citations/1995638http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1995638
http://purl.uniprot.org/citations/1995638http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1995638