| http://purl.uniprot.org/citations/19958189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19958189 | http://www.w3.org/2000/01/rdf-schema#comment | "Hereditary persistence of fetal hemoglobin (HPFH) is characterized by increased levels of Hb F during adult life. Nondeletional forms of HPFH are characterized by single base mutations in the (A)gamma and (G)gamma promoters, resulting in an increase of Hb F ranging from 3 to 20% in heterozygotes. Many point mutations in this region have been described, including the (A)gamma -195 (C>G) mutation that causes the Brazilian type of HPFH (HPFH-B). To better understand this mechanism, we have developed HPFH-B transgenic mice. mRNA levels of human gamma-globin of -195 transgenic mice were clearly higher when compared with control transgenic mice bearing a wild type sequence of the gamma promoter. Thus, our data indicate that the -195 mutation is the unique cause of elevation of Hb F in Brazilian HPFH. These results could provide us with an opportunity to study the modifying effects of the Hb F in the phenotype of sickle cell disease and beta-thalassemia (beta-thal)."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.org/dc/terms/identifier | "doi:10.3109/03630260903344176"xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "Costa F.F."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "da Cunha A.F."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "Saad S.T."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "Bodine D."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "de Melo M.B."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "Corat M.A."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "Devlin E.E."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "Brugnerotto A.F."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "Gimenes A.P."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/author | "Passos L.A."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/name | "Hemoglobin"xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/pages | "439-447"xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/title | "High levels of human gamma-globin are expressed in adult mice carrying a transgene of the Brazilian type of hereditary persistence of fetal hemoglobin ((A)gamma -195)."xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/19958189 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19958189 |
| http://purl.uniprot.org/citations/19958189 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19958189 |
| http://purl.uniprot.org/uniprot/#_A0A7D5JSC0-mappedCitation-19958189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19958189 |
| http://purl.uniprot.org/uniprot/#_D9YZU8-mappedCitation-19958189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19958189 |
| http://purl.uniprot.org/uniprot/#_B8XXQ5-mappedCitation-19958189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19958189 |
| http://purl.uniprot.org/uniprot/#_D3GKD8-mappedCitation-19958189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19958189 |
| http://purl.uniprot.org/uniprot/#_Q14412-mappedCitation-19958189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19958189 |