| http://purl.uniprot.org/citations/19962960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19962960 | http://www.w3.org/2000/01/rdf-schema#comment | "The tumor suppressor, RASSF2 (Ras association domain family 2), is frequently downregulated in a number of cancers. Although exogenously expressed RASSF2 induces apoptotic cell death, the precise roles of RASSF2 under pro-apoptotic conditions remain largely unknown. Here, we demonstrate that MST1 (mammalian sterile 20-like kinase 1) regulates RASSF2 protein stability. Knockdown of MST1 in cancer cells markedly destabilizes RASSF2, and Mst1-deficient mice show reduced Rassf2 protein levels in several organs. Conversely, RASSF2 activates MST1 kinase activity through formation of a RASSF2-MST1 complex, which inhibits the MST-FOXO3 signaling pathway. RASSF2 also engages the JNK pathway and induces apoptosis in an MST1-independent manner. Collectively, these findings indicate that MST1 is a major determinant of RASSF2 protein stability, and suggest that RASSF2 acts in a complex manner that extends beyond simple protein-protein association to play an important role in MST1 regulation."xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.11.175"xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/author | "Oh S."xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/author | "Oh H.J."xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/author | "Lim D.S."xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/pages | "969-973"xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/title | "Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity."xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://purl.uniprot.org/core/volume | "391"xsd:string |
| http://purl.uniprot.org/citations/19962960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19962960 |
| http://purl.uniprot.org/citations/19962960 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19962960 |
| http://purl.uniprot.org/uniprot/P50749#attribution-4A5A7000956A559EB46B4A6AB22A266E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/P50749#attribution-578109FB0B52BCB087C086FCABEA0D9A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/Q8BMS9#attribution-E2A49812E2EBE3F1238D996AE8940A5C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/Q9JI11#attribution-B186C93D03FE4929041CAE321789864E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/Q9JI11#attribution-E2A49812E2EBE3F1238D996AE8940A5C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/Q13043#attribution-4A5A7000956A559EB46B4A6AB22A266E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/Q13043#attribution-578109FB0B52BCB087C086FCABEA0D9A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/Q9JI10#attribution-E2A49812E2EBE3F1238D996AE8940A5C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/Q13188#attribution-4A5A7000956A559EB46B4A6AB22A266E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/#_A0A087WVN8-mappedCitation-19962960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19962960 |
| http://purl.uniprot.org/uniprot/#_A2A5M9-mappedCitation-19962960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19962960 |