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| http://purl.uniprot.org/citations/19965435 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms that achieve homeostatic stabilization of neural function remain largely unknown. To better understand how neural function is stabilized during development and throughout life, we used an electrophysiology-based forward genetic screen and assessed the function of more than 250 neuronally expressed genes for a role in the homeostatic modulation of synaptic transmission in Drosophila. This screen ruled out the involvement of numerous synaptic proteins and identified a critical function for dysbindin, a gene linked to schizophrenia in humans. We found that dysbindin is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx. Thus, dysbindin is essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease."xsd:string |
| http://purl.uniprot.org/citations/19965435 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1179685"xsd:string |
| http://purl.uniprot.org/citations/19965435 | http://purl.uniprot.org/core/author | "Dickman D.K."xsd:string |
| http://purl.uniprot.org/citations/19965435 | http://purl.uniprot.org/core/author | "Davis G.W."xsd:string |
| http://purl.uniprot.org/citations/19965435 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19965435 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/19965435 | http://purl.uniprot.org/core/pages | "1127-1130"xsd:string |
| http://purl.uniprot.org/citations/19965435 | http://purl.uniprot.org/core/title | "The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis."xsd:string |
| http://purl.uniprot.org/citations/19965435 | http://purl.uniprot.org/core/volume | "326"xsd:string |
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