| http://purl.uniprot.org/citations/19965664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19965664 | http://www.w3.org/2000/01/rdf-schema#comment | "Rituximab (RTX), a monoclonal antibody directed against the CD20 protein, is a drug commonly used in the treatment of B-cell-derived lymphoid neoplasias and of antibody-mediated autoimmune diseases. In addition to cell- and complement-mediated B-cell depletion, RTX is thought to inhibit B-cell survival and proliferation through negative regulation of canonical signaling pathways involving Akt, ERK, and mammalian target of rapamycin. However, surprisingly, although B-cell receptor (BCR) signaling has been considered critical for normal and more recently, for neoplastic B cells, the hypothesis that RTX could target BCR has never been investigated. Using follicular lymphoma cell lines as models, as well as normal B cells, we show here, for the first time, that pretreatment with RTX results in a time-dependent inhibition of the BCR-signaling cascade involving Lyn, Syk, PLC gamma 2, Akt, and ERK, and calcium mobilization. The inhibitory effect of RTX correlates with decrease of raft-associated cholesterol, complete inhibition of BCR relocalization into lipid raft microdomains, and down-regulation of BCR immunoglobulin expression. Thus, RTX-mediated alteration of BCR expression, dynamics, and signaling might contribute to the immunosuppressive activity of the drug."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-08-237537"xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/author | "Gross E."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/author | "Caron P."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/author | "Laurent G."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/author | "Bertrand-Michel J."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/author | "Quillet-Mary A."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/author | "Bezombes C."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/author | "Fournie J.J."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/author | "Kheirallah S."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/pages | "985-994"xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/title | "Rituximab inhibits B-cell receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/19965664 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19965664 |
| http://purl.uniprot.org/citations/19965664 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19965664 |
| http://purl.uniprot.org/uniprot/#_B3KVH4-mappedCitation-19965664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965664 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D6-mappedCitation-19965664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965664 |
| http://purl.uniprot.org/uniprot/#_A0A142IKA9-mappedCitation-19965664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965664 |
| http://purl.uniprot.org/uniprot/#_A8K379-mappedCitation-19965664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965664 |
| http://purl.uniprot.org/uniprot/#_A8K4G2-mappedCitation-19965664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965664 |
| http://purl.uniprot.org/uniprot/#_B4E3H3-mappedCitation-19965664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965664 |
| http://purl.uniprot.org/uniprot/#_B3KQJ1-mappedCitation-19965664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965664 |