| http://purl.uniprot.org/citations/19965673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19965673 | http://www.w3.org/2000/01/rdf-schema#comment | "Several clinical studies done with intravenous immunoglobulin (IVIg)-treated autoimmune patients as well as several in vitro studies have revealed that IVIg can reduce polyclonal T-cell activation and modify their cytokine secretion pattern. However, their effect on (auto)antigen-specific T-cell responses has never been addressed directly. In the present work, we used an in vivo model of induction of antigen-specific T-cell responses and an in vitro antigen presentation system to study the effects of IVIg on T-cell responses. The results obtained showed that IVIg inhibited both the in vivo and in vitro antigen-specific T-cell responses but that this effect was the indirect consequence of a reduction in the antigen presentation ability of antigen-presenting cells. The inhibitory effect of IVIg was FcgammaRIIb-independent, suggesting that IVIg must interfere with activating FcgammaRs expressed on antigen-presenting cells to reduce their ability to present antigens. Such inhibition of T-cell responses by reducing antigen presentation may therefore contribute to the well-known anti-inflammatory effects of IVIg in autoimmune diseases."xsd:string |
| http://purl.uniprot.org/citations/19965673 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-06-225417"xsd:string |
| http://purl.uniprot.org/citations/19965673 | http://purl.uniprot.org/core/author | "Bazin R."xsd:string |
| http://purl.uniprot.org/citations/19965673 | http://purl.uniprot.org/core/author | "Lemieux R."xsd:string |
| http://purl.uniprot.org/citations/19965673 | http://purl.uniprot.org/core/author | "Aubin E."xsd:string |
| http://purl.uniprot.org/citations/19965673 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19965673 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19965673 | http://purl.uniprot.org/core/pages | "1727-1734"xsd:string |
| http://purl.uniprot.org/citations/19965673 | http://purl.uniprot.org/core/title | "Indirect inhibition of in vivo and in vitro T-cell responses by intravenous immunoglobulins due to impaired antigen presentation."xsd:string |
| http://purl.uniprot.org/citations/19965673 | http://purl.uniprot.org/core/volume | "115"xsd:string |
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