| http://purl.uniprot.org/citations/19965872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19965872 | http://www.w3.org/2000/01/rdf-schema#comment | "Aberrant epithelial-mesenchymal transition (EMT) is involved in development of fibrotic disorders and cancer invasion. Alterations of cell-extracellular matrix interaction also contribute to those pathological conditions. However, the functional interplay between EMT and cell-extracellular matrix interactions remains poorly understood. We now show that the inflammatory mediator tumor necrosis factor-alpha (TNF-alpha) induces the formation of fibrotic foci by cultured retinal pigment epithelial cells through activation of transforming growth factor-beta (TGF-beta) signaling in a manner dependent on hyaluronan-CD44-moesin interaction. TNF-alpha promoted CD44 expression and moesin phosphorylation by protein kinase C, leading to the pericellular interaction of hyaluronan and CD44. Formation of the hyaluronan-CD44-moesin complex resulted in both cell-cell dissociation and increased cellular motility through actin remodeling. Furthermore, this complex was found to be associated with TGF-beta receptor II and clathrin at actin microdomains, leading to activation of TGF-beta signaling. We established an in vivo model of TNF-alpha-induced fibrosis in the mouse eye, and such ocular fibrosis was attenuated in CD44-null mice. The production of hyaluronan and its interaction with CD44, thus, play an essential role in TNF-alpha-induced EMT and are potential therapeutic targets in fibrotic disorders."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.056523"xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Nakamura S."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Koga H."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Shinoda T."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Takahashi E."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Ishimoto T."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Ikeda S."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Saya H."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Tanihara H."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Niwa S."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Nagano O."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/author | "Yae T."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/pages | "4060-4073"xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/title | "Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction."xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/19965872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19965872 |
| http://purl.uniprot.org/citations/19965872 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19965872 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXU9-mappedCitation-19965872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965872 |
| http://purl.uniprot.org/uniprot/#_P15379-mappedCitation-19965872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965872 |
| http://purl.uniprot.org/uniprot/#_A2APM1-mappedCitation-19965872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19965872 |