| http://purl.uniprot.org/citations/19995943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19995943 | http://www.w3.org/2000/01/rdf-schema#comment | "Mechanical ventilation is a life-saving therapy that can also damage the lungs. Ventilator-induced lung injury (VILI) promotes inflammation and up-regulates matrix metalloproteinases (MMPs). Among these enzymes, MMP-8 is involved in the onset of inflammation by processing different immune mediators. To clarify the role of MMP-8 in a model of VILI and their relevance as a therapeutic target, we ventilated wild-type and MMP-8-deficient mice with low or high pressures for 2 hours. There were no significant differences after low-pressure ventilation between wild-type and knockout animals. However, lack of MMP-8 results in better gas exchange, decreased lung edema and permeability, and diminished histological injury after high-pressure ventilation. Mmp8(-/-) mice had a different immune response to injurious ventilation, with decreased neutrophilic infiltration, lower levels of IFN-γ and chemokines (LPS-induced CXC chemokine, macrophage inflammatory protein-2), and significant increases in anti-inflammatory cytokines (IL-4, IL-10) in lung tissue and bronchoalveolar lavage fluid. There were no differences in MMP-2, MMP-9, or tissue inhibitor of metalloproteinase-1 between wild-type and knockout mice. These results were confirmed by showing a similar protective effect in wild-type mice treated with a selective MMP-8 inhibitor. We conclude that MMP-8 promotes acute inflammation after ventilation with high pressures, and its short-term inhibition could be a therapeutic goal to limit VILI."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2009-0034oc"xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Lopez-Otin C."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Puente X.S."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Fueyo A."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Cabrera S."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Gutierrez-Fernandez A."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Astudillo A."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Gonzalez-Lopez A."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Parra D."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Campestre C."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Albaiceta G.M."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Garcia-Prieto E."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/author | "Taboada F."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/pages | "555-563"xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/title | "Absence or inhibition of matrix metalloproteinase-8 decreases ventilator-induced lung injury."xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/19995943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19995943 |
| http://purl.uniprot.org/citations/19995943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19995943 |
| http://purl.uniprot.org/uniprot/#_O70138-mappedCitation-19995943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19995943 |
| http://purl.uniprot.org/uniprot/#_Q3TCE6-mappedCitation-19995943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19995943 |
| http://purl.uniprot.org/uniprot/#_Q3TAV4-mappedCitation-19995943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19995943 |