| http://purl.uniprot.org/citations/19998449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19998449 | http://www.w3.org/2000/01/rdf-schema#comment | "Transforming growth factor beta1 (TGFB1) acts as a growth inhibitor of normal colonic epithelial cells, however, as a tumor promoter of colorectal cancer (CRC) cells. To explore the association between genetic polymorphisms in the TGFB1 pathway and CRC susceptibility and clinical outcome, we carried out a case-control study on a Swedish population of 308 CRC cases and 585 age- and gender-matched controls. The cases were sampled prospectively and had up to 16 years follow-up, making the study material particularly suitable for survival analysis. On the basis of their reported or predicted functional effect, nine single-nucleotide polymorphisms (TGFB1: Leu10Pro; TGFBR1: 9A/6A and IVS7G+24A; FURIN: C-229T; THBS1: T+42C; LTBP1L: C-256G; LTBP4: T-893G and Thr750Ala; BAMBI: T-779A) were selected for genotyping. We evaluated the associations between genotypes and CRC and Dukes' stage. Survival probabilities were compared between different subgroups. The observed statistically significant associations included a decreased CRC risk for TGFBR1 IVS7G+24A minor allele carriers (odds ratio (OR): 0.72, 95% confidence interval (CI): 0.53-0.97), less aggressive tumors with Dukes' stage A+B for carriers of LTBP4 Thr750Ala and BAMBI T-779A minor alleles (OR: 0.58, 95%CI: 0.36-0.93 and OR: 0.51, 95%CI: 0.29-0.89, respectively) and worse survival for FURIN C-229T heterozygotes (hazard ratio: 1.63, 95%CI: 1.08-2.46). As this is the first study about the influence of the polymorphisms in the TGFB1 pathway on CRC progression, further studies in large independent cohorts are warranted."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.org/dc/terms/identifier | "doi:10.1002/gcc.20738"xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Wagner K."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Hemminki K."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Altieri A."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Hallmans G."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Lenner P."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Forsti A."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Enquist K."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Palmqvist R."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/author | "Tavelin B."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/name | "Genes Chromosomes Cancer"xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/pages | "270-281"xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/title | "Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression."xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/19998449 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19998449 |
| http://purl.uniprot.org/citations/19998449 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19998449 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DH07-mappedCitation-19998449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19998449 |
| http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-19998449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19998449 |
| http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-19998449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19998449 |
| http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-19998449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19998449 |
| http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-19998449 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19998449 |