| http://purl.uniprot.org/citations/20001236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20001236 | http://www.w3.org/2000/01/rdf-schema#comment | "In chronic lymphocytic leukemia (CLL), inhibition of spontaneous apoptosis determines a worse prognosis and increasing evidences show that disease progression relies also upon cycling CLL cells. We investigated bcl-2, as measure of apoptosis, and CD71, as measure of proliferation, by flow cytometry in 265 patients with CLL. Combining bcl-2 with CD71 values, we defined three subgroups: (1) bcl2 - CD71-; (2) bcl2 + CD71+; and (3) bcl2 + CD71- or bcl2-CD71+. Both a shorter progression-free survival (PFS) and overall survival (OS) were observed in ZAP-70+ (p < 0.00001) and in patients with bcl2 + CD71+ (p < 0.00001 and p = 0.02). The patients with discordant in bcl2 + CD71- and bcl2-CD71+ showed an intermediate outcome. Noteworthy, patients with bcl2 + CD71+ showed a shorter PFS within ZAP-70 negative subgroup (p = 0.00009). In multivariate analysis of PFS, age (p = 0.005), beta-(2) microglobulin (B(2)-M) (p = 0.003), bcl-2 (p = 0.004), CD49d (p = 0.001), and ZAP-70 (p < 0.001) resulted to be significant prognostic factors. The independent prognostic significance of B(2)-M (p = 0.009) and bcl-2 (p = 0.03) was confirmed within ZAP-70 negative patients. Bcl-2 and CD71 can be considered as interesting progression indicators, which should be validated in an independent cohort of patients, to take timely therapeutic decisions in CLL."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.org/dc/terms/identifier | "doi:10.3109/10428190903350421"xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Catalano G."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Bruno A."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Rossi F.M."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Gattei V."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Venditti A."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Amadori S."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Buccisano F."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Del Poeta G."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Del Principe M.I."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Maurillo L."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Ammatuna E."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Bulian P."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Zucchetto A."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "De Fabritiis P."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/author | "Simotti C."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/name | "Leuk Lymphoma"xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/pages | "95-106"xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/title | "Spontaneous apoptosis and proliferation detected by BCL-2 and CD71 proteins are important progression indicators within ZAP-70 negative chronic lymphocytic leukemia."xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/20001236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20001236 |
| http://purl.uniprot.org/citations/20001236 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20001236 |