| http://purl.uniprot.org/citations/20005803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20005803 | http://www.w3.org/2000/01/rdf-schema#comment | "How body size is determined is a long-standing question in biology, yet its regulatory mechanisms remain largely unknown. Here, we find that a conserved microRNA miR-8 and its target, USH, regulate body size in Drosophila. miR-8 null flies are smaller in size and defective in insulin signaling in fat body that is the fly counterpart of liver and adipose tissue. Fat body-specific expression and clonal analyses reveal that miR-8 activates PI3K, thereby promoting fat cell growth cell-autonomously and enhancing organismal growth non-cell-autonomously. Comparative analyses identify USH and its human homolog, FOG2, as the targets of fly miR-8 and human miR-200, respectively. USH/FOG2 inhibits PI3K activity, suppressing cell growth in both flies and humans. FOG2 directly binds to p85alpha, the regulatory subunit of PI3K, and interferes with the formation of a PI3K complex. Our study identifies two novel regulators of insulin signaling, miR-8/miR-200 and USH/FOG2, and suggests their roles in adolescent growth, aging, and cancer."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2009.11.020"xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/author | "Jin H."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/author | "Lee G."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/author | "Kim V.N."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/author | "Nam J."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/author | "Hyun S."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/author | "Namkoong B."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/pages | "1096-1108"xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/title | "Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K."xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://purl.uniprot.org/core/volume | "139"xsd:string |
| http://purl.uniprot.org/citations/20005803 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20005803 |
| http://purl.uniprot.org/citations/20005803 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20005803 |
| http://purl.uniprot.org/uniprot/Q9VPQ6#attribution-B9082B6AFA81CB4DB963EB6501C7C8ED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20005803 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LIA3-mappedCitation-20005803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005803 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCT8-mappedCitation-20005803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005803 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KGN1-mappedCitation-20005803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005803 |
| http://purl.uniprot.org/uniprot/#_A0A126GUT4-mappedCitation-20005803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005803 |
| http://purl.uniprot.org/uniprot/#_A8DZ18-mappedCitation-20005803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005803 |
| http://purl.uniprot.org/uniprot/#_B4DZR3-mappedCitation-20005803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005803 |