| http://purl.uniprot.org/citations/20005871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20005871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20005871 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclei migrate during many events, including fertilization, establishment of polarity, differentiation, and cell division. The Caenorhabditis elegans KASH protein UNC-83 localizes to the outer nuclear membrane where it recruits kinesin-1 to provide the major motor activity required for nuclear migration in embryonic hyp7 cells. Here we show that UNC-83 also recruits two dynein-regulating complexes to the cytoplasmic face of the nucleus that play a regulatory role. One consists of the NudE homolog NUD-2 and the NudF/Lis1/Pac1 homolog LIS-1, and the other includes dynein light chain DLC-1, the BicaudalD homolog BICD-1, and the Egalitarian homologue EGAL-1. Genetic disruption of any member of these two complexes caused nuclear migration defects that were enhanced in some double mutant animals, suggesting that BICD-1 and EGAL-1 function in parallel to NUD-2. Dynein heavy chain mutant animals also had a nuclear migration defect, suggesting these complexes function through dynein. Deletion analysis indicated that independent domains of UNC-83 interact with kinesin and dynein. These data suggest a model where UNC-83 acts as the cargo-specific adaptor between the outer nuclear membrane and the microtubule motors kinesin-1 and dynein. Kinesin-1 functions as the major force generator during nuclear migration, while dynein is involved in regulation of bidirectional transport of the nucleus."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2009.12.004"xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2009.12.004"xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/author | "Ly N."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/author | "Ly N."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/author | "Starr D.A."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/author | "Starr D.A."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/author | "Fridolfsson H.N."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/author | "Fridolfsson H.N."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/author | "Meyerzon M."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/author | "Meyerzon M."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/name | "Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/pages | "237-250"xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/pages | "237-250"xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/title | "UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/title | "UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration."xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/volume | "338"xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://purl.uniprot.org/core/volume | "338"xsd:string |
| http://purl.uniprot.org/citations/20005871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20005871 |
| http://purl.uniprot.org/citations/20005871 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20005871 |