| http://purl.uniprot.org/citations/20005944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20005944 | http://www.w3.org/2000/01/rdf-schema#comment | "Sauchinone, as an AMP-activated kinase (AMPK)-activating lignan in Saururus chinensis, has been shown to prevent iron-induced oxidative stress and liver injury. Sterol regulatory element binding protein-1c (SREBP-1c) plays a key role in hepatic steatosis, which promotes oxidative stress in obese subjects. Previously, we identified the role of AMPK in liver X receptor-alpha (LXRalpha)-mediated SREBP-1c-dependent lipogenesis. Because sauchinone as an antioxidant has the ability to activate AMPK, this study investigated its effects on SREBP-1c-dependent lipogenesis in hepatocytes and in high-fat diet (HFD)-induced hepatic steatosis and oxidative injury. Sauchinone prevented the ability of an LXRalpha agonist (T0901317) to activate SREBP-1c, repressing transcription of the fatty acid synthase, acetyl-CoA carboxylase, stearoyl-CoA desaturase-1, ATP-binding cassette transporter A1, and LXRalpha genes. Consistent with this, an HFD in mice caused fat accumulation in the liver with SREBP-1c induction, which was attenuated by sauchinone treatment. Also, sauchinone had the ability to inhibit oxidative stress as shown by decreases in thiobarbituric acid-reactive substance formation, nitrotyrosinylation, and 4-hydroxynonenal production. Moreover, it prevented not only the liver injury, but also the AMPK inhibition elicited by HFD feeding. These results demonstrate that sauchinone has the capability to inhibit LXRalpha-mediated SREBP-1c induction and SREBP-1c-dependent hepatic steatosis, thereby protecting hepatocytes from oxidative stress induced by fat accumulation."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.freeradbiomed.2009.12.006"xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/author | "Kim Y.W."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/author | "Kim Y.M."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/author | "Kim S.C."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/author | "Kim S.G."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/author | "Hwang S.J."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/author | "Lee J.R."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/author | "Kim T.H."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/author | "Yang Y.M."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/name | "Free Radic Biol Med"xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/pages | "567-578"xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/title | "Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis."xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://purl.uniprot.org/core/volume | "48"xsd:string |
| http://purl.uniprot.org/citations/20005944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20005944 |
| http://purl.uniprot.org/citations/20005944 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20005944 |
| http://purl.uniprot.org/uniprot/#_P56720-mappedCitation-20005944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005944 |
| http://purl.uniprot.org/uniprot/#_B4DGV9-mappedCitation-20005944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005944 |
| http://purl.uniprot.org/uniprot/#_A6HF27-mappedCitation-20005944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005944 |
| http://purl.uniprot.org/uniprot/#_A6HF28-mappedCitation-20005944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005944 |
| http://purl.uniprot.org/uniprot/#_B2R8B9-mappedCitation-20005944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005944 |
| http://purl.uniprot.org/uniprot/#_B6ZGS8-mappedCitation-20005944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005944 |
| http://purl.uniprot.org/uniprot/#_A8MTU8-mappedCitation-20005944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20005944 |