| http://purl.uniprot.org/citations/20006577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20006577 | http://www.w3.org/2000/01/rdf-schema#comment | "SNARE proteins (VAMP2, syntaxin4, and SNAP23) have been thought to play a key role in GLUT4 trafficking by mediating the tethering, docking and subsequent fusion of GLUT4-containing vesicles with the plasma membrane. The precise functions of these proteins have remained elusive, however. We have now shown that depletion of the vesicle SNARE (v-SNARE) VAMP2 by RNA interference in 3T3-L1 adipocytes inhibited the fusion of GLUT4 vesicles with the plasma membrane but did not affect tethering of the vesicles to the membrane. In contrast, depletion of the target SNAREs (t-SNAREs) syntaxin4 or SNAP23 resulted in impairment of GLUT4 vesicle tethering to the plasma membrane. Our results indicate that the t-SNAREs syntaxin4 and SNAP23 are indispensable for the tethering of GLUT4 vesicles to the plasma membrane, whereas the v-SNARE VAMP2 is not required for this step but is essential for the subsequent fusion event."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.12.045"xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/author | "Yoshikawa M."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/author | "Kasuga M."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/author | "Kawaguchi T."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/author | "Nishino N."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/author | "Kanda H."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/author | "Tamori Y."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/author | "Tateya S."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/pages | "1336-1341"xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/title | "The t-SNAREs syntaxin4 and SNAP23 but not v-SNARE VAMP2 are indispensable to tether GLUT4 vesicles at the plasma membrane in adipocyte."xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://purl.uniprot.org/core/volume | "391"xsd:string |
| http://purl.uniprot.org/citations/20006577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20006577 |
| http://purl.uniprot.org/citations/20006577 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20006577 |
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| http://purl.uniprot.org/uniprot/#_B0QZN5-mappedCitation-20006577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20006577 |
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| http://purl.uniprot.org/uniprot/#_E9Q8A1-mappedCitation-20006577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20006577 |
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