| http://purl.uniprot.org/citations/20007359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20007359 | http://www.w3.org/2000/01/rdf-schema#comment | "Japanese encephalitis is characterized by profound neuronal destruction/dysfunction and concomitant microgliosis/astrogliosis. Although substantial activation of glia is observed in Japanese encephalitis virus (JEV)-induced Japanese encephalitis, the inflammatory responses and consequences of astrocytes and microglial activation after JEV infection are not fully understood. In this study, infection of cultured neurons/glia with JEV caused neuronal death and glial activation, as evidenced by morphological transformation, increased cell proliferation and elevated tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6 and RANTES (regulated upon activation, normal T-cell expressed and secreted) production. Replication-competent JEV caused all glial responses and neurotoxicity. However, replication-incompetent JEV lost these abilities, except for the ability to change microglial morphology. The bystander damage caused by activated glia also contributed to JEV-associated neurotoxicity. Microglia underwent morphological changes, increased cell proliferation and elevated TNF-alpha, IL-1beta, IL-6 and RANTES expression in response to JEV infection. In contrast, IL-6 and RANTES expression, but no apparent morphological changes, proliferation or TNF-alpha/IL-1beta expression, was demonstrated in JEV-infected astrocytes. Supernatants of JEV-infected microglia, but not JEV-infected astrocytes, induced glial activation and triggered neuronal death. Antibody neutralization studies revealed that TNF-alpha and IL-1beta, but not RANTES or IL-6, released by activated microglia appeared to play roles in JEV-associated neurotoxicity. In conclusion, following JEV infection, neuronal death was accompanied by concomitant microgliosis and astrogliosis, and neurotoxic mediators released by JEV-activated microglia, rather than by JEV-activated astrocytes, had the ability to amplify the microglial response and cause neuronal death."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.org/dc/terms/identifier | "doi:10.1099/vir.0.013565-0"xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/author | "Chen C.J."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/author | "Chen J.H."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/author | "Lin S.Y."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/author | "Lai C.Y."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/author | "Chen S.Y."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/author | "Liao S.L."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/author | "Raung S.L."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/author | "Ou Y.C."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/name | "J Gen Virol"xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/pages | "1028-1037"xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/title | "Glial activation involvement in neuronal death by Japanese encephalitis virus infection."xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/20007359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20007359 |
| http://purl.uniprot.org/citations/20007359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20007359 |
| http://purl.uniprot.org/uniprot/#_F7FLW4-mappedCitation-20007359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20007359 |
| http://purl.uniprot.org/uniprot/#_P50231-mappedCitation-20007359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20007359 |
| http://purl.uniprot.org/uniprot/#_Q6PED1-mappedCitation-20007359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20007359 |
| http://purl.uniprot.org/uniprot/F7FLW4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20007359 |
| http://purl.uniprot.org/uniprot/Q6PED1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20007359 |
| http://purl.uniprot.org/uniprot/P50231 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20007359 |