| http://purl.uniprot.org/citations/20007583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20007583 | http://www.w3.org/2000/01/rdf-schema#comment | "The soluble form of vascular endothelial growth factor receptor-1 (sVEGFR-1) is produced from endothelial cells by alternative splicing of VEGFR-1 mRNA, and can inhibit angiogenesis by blocking the biological effects of VEGF. In this study, we show the expression of a large amount of sVEGFR-1 in human monocyte-derived mature dendritic cells (mDCs). As compared with monocytes and immature DCs, mDCs generated by TNF-alpha or soluble CD40L with IFN-gamma, but not LPS or other stimuli, preferentially produce sVEGFR-1. We also detected the mRNA of sVEGFR-1 generated by alternative splicing of VEGFR-1 mRNA in mDCs induced by TNF-alpha. The production of sVEGFR-1 showed a distinct contrast to those of VEGF in each DC matured with various stimuli. The supernatant of DCs matured with TNF-alpha or soluble CD40L with IFN-gamma showed inhibition of the tube formation of HUVECs, which was neutralized by anti-VEGFR-1 Ab, indicating that sVEGFR-1 secreted from mDCs was biologically active. Interestingly, the supernatant of mDCs generated with LPS increased HUVEC capillary-like formation in vitro. The ratio of sVEGFR-1 to VEGF clearly reflected the net angiogenic property of mDCs. Administration of mDCs induced by TNF-alpha into the s.c. tumor of PC-14 cells implanted in SCID mice demonstrated the inhibition of tumor growth via reduction of the number of CD31-positive vessels, indicating their in vivo antiangiogenic potential. These results suggest that sVEGFR-1 produced by mDCs contribute to their antiangiogenic property, and the ratio of sVEGFR-1 to VEGF might be a useful tool for evaluating their ability to regulate angiogenesis mediated by VEGF."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0803849"xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Makino H."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Abe S."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Ogino H."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Kinoshita K."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Ranjan P."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Minakuchi K."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Nishioka Y."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Sone S."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Kishi J."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Aono Y."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Batmunkh R."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Kishuku M."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/author | "Rentsenhand B."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/pages | "8176-8185"xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/title | "Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property."xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/20007583 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20007583 |
| http://purl.uniprot.org/citations/20007583 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20007583 |
| http://purl.uniprot.org/uniprot/#_H9N1E7-mappedCitation-20007583 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20007583 |