| http://purl.uniprot.org/citations/20007903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20007903 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20007903 | http://www.w3.org/2000/01/rdf-schema#comment | "Metabotropic glutamate receptor 5 (mGluR5) is highly expressed in the mammalian central nervous system (CNS). It is involved in multiple physiological functions and is a target for treatment of various CNS disorders, including schizophrenia. We report that Norbin, a neuron-specific protein, physically interacts with mGluR5 in vivo, increases the cell surface localization of the receptor, and positively regulates mGluR5 signaling. Genetic deletion of Norbin attenuates mGluR5-dependent stable changes in synaptic function measured as long-term depression or long-term potentiation of synaptic transmission in the hippocampus. As with mGluR5 knockout mice or mice treated with mGluR5-selective antagonists, Norbin knockout mice showed a behavioral phenotype associated with a rodent model of schizophrenia, as indexed by alterations both in sensorimotor gating and psychotomimetic-induced locomotor activity."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1178496"xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1178496"xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Flajolet M."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Flajolet M."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Birnbaum S."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Birnbaum S."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Aperia A."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Aperia A."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Brismar H."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Brismar H."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Bendor J."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Bendor J."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Nestler E."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Nestler E."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Nong Y."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Nong Y."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Westin L."xsd:string |
| http://purl.uniprot.org/citations/20007903 | http://purl.uniprot.org/core/author | "Westin L."xsd:string |