| http://purl.uniprot.org/citations/20008143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20008143 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-11 (IL-11) up-regulates the proliferative and invasive capacity of many cancers. Coexpression of glycoprotein 130 (GP130) and IL-11 receptor alpha (IL-11Ralpha) is necessary for high-affinity binding of IL-11 to IL-11Ralpha. This study investigated the expression of IL-11 and role of prostaglandin F(2alpha)-F-prostanoid receptor (FP receptor) signaling in the modulation of IL-11 expression in endometrial adenocarcinoma cells. Localization of IL-11, IL-11Ralpha, and GP130 expression was performed by immunohistochemistry. IL-11 and regulator of calcineurin 1 isoform 4 (RCAN1-4) mRNA and protein expression were determined by real-time RT-PCR and/or enzyme-linked immunosorbent assay/Western blot analysis using Ishikawa endometrial adenocarcinoma cells stably expressing the FP receptor (FPS cells) and endometrial adenocarcinoma explants. IL-11 mRNA expression was significantly elevated in endometrial adenocarcinoma samples compared with normal endometrium and increased with tumor grade. IL-11 protein expression localized with FP receptor, IL-11Ralpha, and GP130 in the neoplastic glandular epithelium of endometrial adenocarcinomas. Prostaglandin F(2alpha)-FP receptor signaling significantly elevated the expression of IL-11 mRNA and protein in a Gq-protein kinase C-calcium-calcineurin-nuclear factor of activated T cells-dependent manner in FPS cells. The calcineurin signaling pathway is known to be controlled by the RCAN (RCAN1-4). Indeed, RCAN1-4 expression was significantly elevated in well-differentiated endometrial adenocarcinoma compared with normal endometrium and was found to decrease with tumor grade and negatively regulate IL-11 expression in vitro. This study has highlighted a new mechanism regulating IL-11 expression in endometrial adenocarcinoma cells by the FP receptor via the calcium-calcineurin-nuclear factor of activated T cells pathway."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2010.090403"xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/author | "Anderson R.A."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/author | "Williams A.R."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/author | "Jabbour H.N."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/author | "Sales K.J."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/author | "Grant V."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/author | "Cook I.H."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/author | "Maldonado-Perez D."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/pages | "435-445"xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/title | "Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1."xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/20008143 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20008143 |
| http://purl.uniprot.org/citations/20008143 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20008143 |
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