| http://purl.uniprot.org/citations/20008289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20008289 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we find that CD45RO+ memory populations of CD4+ T lymphocytes express the vascular endothelial growth factor (VEGF) receptors KDR and Flt-1 at both the mRNA and protein levels. Furthermore, by Western blot analysis, we find that VEGF increases the phosphorylation and activation of ERK and Akt within CD4+CD45RO+ T cells. These VEGF-mediated signaling responses were inhibited by a KDR-specific small interfering RNA in a VEGF receptor-expressing Jurkat T cell line and by SU5416, a pharmacological KDR inhibitor, in CD4+CD45RO+ T cells. We also find that VEGF augments mitogen-induced production of IFN-gamma in a dose-dependent manner (p < 0.001) and significantly (p < 0.05) increases directed chemotaxis of this T cell subset. Collectively, our results for the first time define a novel function for VEGF and KDR in CD45RO+ memory T cell responses that are likely of great pathophysiological importance in immunity."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0900397"xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/author | "Basu A."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/author | "Pal S."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/author | "Datta D."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/author | "Briscoe D.M."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/author | "Hoerning A."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/author | "Calzadilla K."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/author | "Edelbauer M."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/author | "Stack M.P."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/pages | "545-549"xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/title | "Cutting edge: Vascular endothelial growth factor-mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and ERK activation and costimulates IFN-gamma production."xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/20008289 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20008289 |
| http://purl.uniprot.org/citations/20008289 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20008289 |
| http://purl.uniprot.org/uniprot/#_A0A0U2WZU8-mappedCitation-20008289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008289 |
| http://purl.uniprot.org/uniprot/#_A0A0U2X4C8-mappedCitation-20008289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008289 |
| http://purl.uniprot.org/uniprot/#_A0A0H4A777-mappedCitation-20008289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008289 |
| http://purl.uniprot.org/uniprot/#_A0A0H4A7S0-mappedCitation-20008289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008289 |
| http://purl.uniprot.org/uniprot/#_A0A0H4A7S4-mappedCitation-20008289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008289 |
| http://purl.uniprot.org/uniprot/#_A0A0H4ADZ1-mappedCitation-20008289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008289 |
| http://purl.uniprot.org/uniprot/#_A0A0H4AF76-mappedCitation-20008289 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008289 |