| http://purl.uniprot.org/citations/20008292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20008292 | http://www.w3.org/2000/01/rdf-schema#comment | "A role for NK cells in therapeutic intervention for hematologic malignancies, such as acute myeloid leukemia and multiple myeloma, and nonhematologic malignancies, such as melanoma, is becoming more apparent. DNAM-1 is an NK cell receptor whose importance in facilitating activation signals received by NK cells in natural and cytokine-driven responses to tumor metastases in vivo is poorly explored. In this study, we used matched tumor lines expressing a variety of relevant ligands, neutralizing monoclonal Abs, and DNAM-1 gene-targeted mice to determine the relative importance of DNAM-1-ligand interactions in controlling tumor metastases. Our results demonstrate that NK cells require DNAM-1 for natural or cytokine (IL-2, IL-12, or IL-21) suppression of tumor metastases or their variants expressing CD70 or CD80. In contrast, DNAM-1 was dispensable when tumor cells were targets of Ab-dependent cellular cytotoxicity or presented ligands for NKG2D. CD155 appeared to be a key ligand recognized by DNAM-1 in NK cell-mediated suppression of metastases, and DNAM-1-mediated suppression coincided with perforin activity. Overall, these data implied a general role for DNAM-1-CD155 interactions in NK cell-mediated killing of tumors, even in the presence of tumor CD70 or CD80 expression, and further defined the optimal efficacy requirements of cytokines that directly activate NK cells."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0903225"xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/author | "Chan C.J."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/author | "Andrews D.M."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/author | "Yagita H."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/author | "Gilfillan S."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/author | "Smyth M.J."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/author | "McLaughlin N.M."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/pages | "902-911"xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/title | "DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases."xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/20008292 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20008292 |
| http://purl.uniprot.org/citations/20008292 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20008292 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-20008292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008292 |
| http://purl.uniprot.org/uniprot/#_A0A494BBC0-mappedCitation-20008292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008292 |
| http://purl.uniprot.org/uniprot/#_A0A494BBL3-mappedCitation-20008292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008292 |
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| http://purl.uniprot.org/uniprot/#_A0A494BB66-mappedCitation-20008292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008292 |
| http://purl.uniprot.org/uniprot/#_A2RSY7-mappedCitation-20008292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008292 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-20008292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008292 |
| http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-20008292 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008292 |