| http://purl.uniprot.org/citations/20008523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20008523 | http://www.w3.org/2000/01/rdf-schema#comment | "A subset of HLA-B*35 alleles, B*35-Px, are strongly associated with accelerated HIV-1 disease progression for reasons that are not understood. Interestingly, the alternative set of B*35 subtypes, B*35-PY, have no detectable impact on HIV-1 disease outcomes, even though they can present identical HIV-1 epitopes as B*35-Px molecules. Thus, the differential impact of these alleles on HIV-1 disease progression may be unrelated to interactions with HIV-1-specific CD8(+) T cells. Here, we show that the B*35-Px molecule B*3503 binds with greater affinity to immunoglobulin-like transcript 4 (ILT4), an inhibitory MHC class I receptor expressed on dendritic cells, than does the B*35-PY molecule B*3501, even though these two B*35 molecules differ by only one amino acid and present identical HIV-1 epitopes. The preferential recognition of B*3503 by ILT4 was associated with significantly stronger dendritic cell dysfunction in in vitro functional assays. Moreover, HIV-1-infected carriers of B*3503 had poor dendritic cell functional properties in ex vivo assessments when compared with carriers of the B*3501 allele. Differential interactions between HLA class I allele subtypes and immunoregulatory MHC class I receptors on dendritic cells thus provide a novel perspective for the understanding of MHC class I associations with HIV-1 disease progression and for the manipulation of host immunity against HIV-1."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20091386"xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Carrington M."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Martin M.P."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Sundberg E.J."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Preiss L."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Goedert J.J."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Yu X.G."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Burke P.S."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Lichterfeld M."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Lifson J."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/author | "Cung T.D."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/pages | "2959-2966"xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/title | "HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses."xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://purl.uniprot.org/core/volume | "206"xsd:string |
| http://purl.uniprot.org/citations/20008523 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20008523 |
| http://purl.uniprot.org/citations/20008523 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20008523 |
| http://purl.uniprot.org/uniprot/P01889#attribution-364D52BEDFC77CC6900D991DFD75FFB1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20008523 |
| http://purl.uniprot.org/uniprot/Q8N423#attribution-131D654A43FC8061AB407574FDE7B8A4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20008523 |
| http://purl.uniprot.org/uniprot/Q8N423#attribution-364D52BEDFC77CC6900D991DFD75FFB1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20008523 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-20008523 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008523 |