| http://purl.uniprot.org/citations/20008566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20008566 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20008566 | http://www.w3.org/2000/01/rdf-schema#comment | "Sterols are transferred between cellular membranes by vesicular and poorly understood nonvesicular pathways. Oxysterol-binding protein-related proteins (ORPs) have been implicated in sterol sensing and nonvesicular transport. In this study, we show that yeast ORPs use a novel mechanism that allows regulated sterol transfer between closely apposed membranes, such as organelle contact sites. We find that the core lipid-binding domain found in all ORPs can simultaneously bind two membranes. Using Osh4p/Kes1p as a representative ORP, we show that ORPs have at least two membrane-binding surfaces; one near the mouth of the sterol-binding pocket and a distal site that can bind a second membrane. The distal site is required for the protein to function in cells and, remarkably, regulates the rate at which Osh4p extracts and delivers sterols in a phosphoinositide-dependent manner. Together, these findings suggest a new model of how ORPs could sense and regulate the lipid composition of adjacent membranes."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200905007"xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200905007"xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Ghirlando R."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Ghirlando R."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Raychaudhuri S."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Raychaudhuri S."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Prinz W.A."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Prinz W.A."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Choi M.G."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Choi M.G."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Hinshaw J.E."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Hinshaw J.E."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Mears J.A."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Mears J.A."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Schulz T.A."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/author | "Schulz T.A."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/pages | "889-903"xsd:string |
| http://purl.uniprot.org/citations/20008566 | http://purl.uniprot.org/core/pages | "889-903"xsd:string |