| http://purl.uniprot.org/citations/20008792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20008792 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphorylated signal transducer and activator of transcription 5 (STAT5) is a biomarker and potential molecular target for hematologic malignancies. We have shown previously that lethal myeloproliferative disease (MPD) in mice mediated by persistently activated STAT5 (STAT5a(S711F)) requires the N-domain, but the mechanism was not defined. We now demonstrate by retrovirally complementing STAT5ab(null/null) primary mast cells that relative to wild-type STAT5a, STAT5a lacking the N-domain (STAT5aDeltaN) ineffectively protected against cytokine withdrawal-induced cell death. Both STAT5a and STAT5aDeltaN bound to a site in the bcl-2 gene and both bound near the microRNA 15b/16 cluster. However, only STAT5a could effectively induce bcl-2 mRNA and reciprocally suppress miR15b/16 leading to maintained bcl-2 protein levels. After retroviral complementation of STAT5ab(null/null) fetal liver cells and transplantation, persistently active STAT5a(S711F) lacking the N-domain (STAT5aDeltaN(S711F)) was insufficient to protect c-Kit(+)Lin(-)Sca-1(+) (KLS) cells from apoptosis and unable to induce bcl-2 expression, whereas STAT5a(S711F) caused robust KLS cell expansion, induction of bcl-2, and lethal MPD. Severe attenuation of MPD by STAT5aDeltaN(S711F) was reversed by H2k/bcl-2 transgenic expression. Overall, these studies define N-domain-dependent survival signaling as an Achilles heel of persistent STAT5 activation and highlight the potential therapeutic importance of targeting STAT5 N-domain-mediated regulation of bcl-2 family members."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-07-234963"xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Bunting K.D."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Ryan J.J."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Moriggl R."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Tse W."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Miskimen K.L."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Xie X.Y."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/author | "Brenzovich J."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/pages | "1416-1424"xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/title | "STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease."xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/20008792 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20008792 |
| http://purl.uniprot.org/citations/20008792 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20008792 |
| http://purl.uniprot.org/uniprot/#_A2A5D3-mappedCitation-20008792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008792 |
| http://purl.uniprot.org/uniprot/#_A2A5D4-mappedCitation-20008792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008792 |
| http://purl.uniprot.org/uniprot/#_B2C3G8-mappedCitation-20008792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008792 |
| http://purl.uniprot.org/uniprot/#_Q71UV3-mappedCitation-20008792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008792 |
| http://purl.uniprot.org/uniprot/#_Q3UZ79-mappedCitation-20008792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008792 |
| http://purl.uniprot.org/uniprot/#_P42230-mappedCitation-20008792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008792 |