| http://purl.uniprot.org/citations/20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20008936 | http://www.w3.org/2000/01/rdf-schema#comment | "Large-scale changes (gross chromosomal rearrangements [GCRs]) are common in genomes, and are often associated with pathological disorders. We report here that a specific pair of nearby inverted repeats in budding yeast fuse to form a dicentric chromosome intermediate, which then rearranges to form a translocation and other GCRs. We next show that fusion of nearby inverted repeats is general; we found that many nearby inverted repeats that are present in the yeast genome also fuse, as does a pair of synthetically constructed inverted repeats. Fusion occurs between inverted repeats that are separated by several kilobases of DNA and share >20 base pairs of homology. Finally, we show that fusion of inverted repeats, surprisingly, does not require genes involved in double-strand break (DSB) repair or genes involved in other repeat recombination events. We therefore propose that fusion may occur by a DSB-independent, DNA replication-based mechanism (which we term "faulty template switching"). Fusion of nearby inverted repeats to form dicentrics may be a major cause of instability in yeast and in other organisms."xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1862709"xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/author | "Jones H."xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/author | "Weinert T."xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/author | "Kaochar S."xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/author | "Shanks L."xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/author | "Elezaby A."xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/author | "Paek A.L."xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/pages | "2861-2875"xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/title | "Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast."xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/20008936 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20008936 |
| http://purl.uniprot.org/citations/20008936 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20008936 |
| http://purl.uniprot.org/uniprot/#_Q12223-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |
| http://purl.uniprot.org/uniprot/#_P10862-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |
| http://purl.uniprot.org/uniprot/#_P06778-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |
| http://purl.uniprot.org/uniprot/#_P14737-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |
| http://purl.uniprot.org/uniprot/#_P12954-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |
| http://purl.uniprot.org/uniprot/#_P47110-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |
| http://purl.uniprot.org/uniprot/#_P25454-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |
| http://purl.uniprot.org/uniprot/#_P35187-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |
| http://purl.uniprot.org/uniprot/#_P35203-mappedCitation-20008936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20008936 |