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Hypothesis

To assess the frequency distribution of the CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer.

Methods

Forty-three Israeli Jewish women with cervical cancer and 123 healthy Israeli Jewish women were assessed. CYP1A1 (2 alleles) and CYP2D6 polymorphism was analyzed using an allele-specific, polymerase chain reaction-based method.

Results

The allele frequency and genotype distribution for the CYP1A1 (2 alleles) and CYP2D6 polymorphism did not reach a level of significance. Smoking was the only independent risk factor for cervical cancer (P = 0.0003).

Conclusion

CYP1A1 and CYP2D6 mutations are not related to an increased risk for cervical cancer in the Jewish Israeli population."xsd:string
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http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/author"Grisaru D."xsd:string
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/author"Gutman G."xsd:string
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/author"Morad T."xsd:string
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/author"Bar-Am A."xsd:string
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/author"Peleg B."xsd:string
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/author"Peretz C."xsd:string
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/author"Safra T."xsd:string
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/name"Int J Gynecol Cancer"xsd:string
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http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/title"CYP1A1 and CYP2D6 gene polymorphisms in Israeli Jewish women with cervical cancer."xsd:string
http://purl.uniprot.org/citations/20009880http://purl.uniprot.org/core/volume"19"xsd:string
http://purl.uniprot.org/citations/20009880http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20009880
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