| http://purl.uniprot.org/citations/20010822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20010822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20010822 | http://www.w3.org/2000/01/rdf-schema#comment | "Sleep is a whole-organism phenomenon accompanied by global changes in neural activity. We previously identified SLEEPLESS (SSS) as a glycosylphosphatidyl inositol-anchored protein required for sleep in Drosophila. Here we found that SSS is critical for regulating the sleep-modulating potassium channel Shaker. SSS and Shaker shared similar expression patterns in the brain and specifically affected each other's expression levels. sleepless (sss) loss-of-function mutants exhibited altered Shaker localization, reduced Shaker current density and slower Shaker current kinetics. Transgenic expression of sss in sss mutants rescued defects in Shaker expression and activity cell-autonomously and suggested that SSS functions in wake-promoting, cholinergic neurons. In heterologous cells, SSS accelerated the kinetics of Shaker currents and was co-immunoprecipitated with Shaker, suggesting that SSS modulates Shaker activity via a direct interaction. SSS is predicted to belong to the Ly-6/neurotoxin superfamily, suggesting a mechanism for regulation of neuronal excitability by endogenous toxin-like molecules."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2454"xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2454"xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Chen D."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Smith C.J."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Smith C.J."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Sehgal A."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Sehgal A."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Hoshi T."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Hoshi T."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Joiner W.J."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Joiner W.J."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Wu M.N."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Wu M.N."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Yue Z."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Yue Z."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Dean T."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Dean T."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Koh K."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/author | "Koh K."xsd:string |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20010822 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |