| http://purl.uniprot.org/citations/20010876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20010876 | http://www.w3.org/2000/01/rdf-schema#comment | "The forced overexpression of c-Myc in mouse prostate and in normal human prostate epithelial cells results in tumor transformation with an invasive phenotype. How c-Myc regulates cell invasion is poorly understood. In this study, we have investigated the interplay of c-Myc and androgens in the regulation of prostate cancer cell invasion. We found that c-Myc induces cell invasion and anchorage-independent growth by regulating ezrin protein expression in the presence of androgens. The activity of the ezrin promoter is controlled by androgens through c-Myc, which binds to a phylogenetically conserved E-Box located in the proximal promoter region. Besides, we also show that ezrin is an important regulator of c-Myc protein levels. These effects are achieved through androgen-induced changes in ezrin phosphorylation, which results in the regulation of downstream signals. These downstream signals involve the modulation of Akt and GSK-3beta activity resulting in increased c-Myc protein synthesis and inhibition of its degradation. In summary, we have shown a key role for ezrin as a mediator of c-Myc-induced tumorigenesis in prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.442"xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/author | "Pang S.T."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/author | "Pousette A."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/author | "Norstedt G."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/author | "Flores-Morales A."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/author | "Cedazo-Minguez A."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/author | "Chuan Y.C."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/author | "Fernandez-Perez L."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/author | "Iglesias-Gato D."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/pages | "1531-1542"xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/title | "Ezrin mediates c-Myc actions in prostate cancer cell invasion."xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20010876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20010876 |
| http://purl.uniprot.org/citations/20010876 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20010876 |
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