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http://purl.uniprot.org/citations/20010906http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20010906http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Neuromedin B (NMB) is a bombesin-like peptide, which inhibits food intake and modulates stress-related behaviour. An NMB gene polymorphism (P73T) has been earlier associated with obesity and abnormal eating behaviour in adults.

Methods

The association between four NMB polymorphisms and obesity-related phenotypes was investigated in the Healthy Lifestyle in Europe by Nutrition in Adolescence cross-sectional study (n=1144, 12-17-year-old European adolescents). This population was genotyped for the NMB rs1107179, rs17598561, rs3809508 and rs1051168 (P73T) polymorphisms. Obesity was defined according to Cole et al. (BMJ 2000; 320:1240-1243) criteria; eating behaviour was assessed by the Eating Behaviour and Weight Problems Inventory for Children (EWI-C) and the food choices and preferences questionnaires. Familial socioeconomic status (SES) was assessed through the parents' educational level.

Results

Only the genotype distribution of rs3809508 differed according to obesity status, as the TT genotype was more frequent in obese than in non-obese adolescents (8.6% vs 3.1%, P=0.05; adjusted odds ratio for obesity (95% confidence interval): 2.85 (1.11-7.31), P=0.03). Moreover, TT subjects had higher body mass index (22.8+/-4.4 kg m(-2) vs 21.3+/-3.7 kg m(-2), P=0.02), waist circumference (75.8+/-9.7 cm vs 72.2+/-9.3 cm, P=0.006), waist-to-hip ratio (0.84+/-0.14 vs 0.79+/-0.07, P<0.0001) and waist-to-height ratio (0.47+/-0.06 vs 0.44+/-0.55, P=0.002) than C allele carriers. The effects of this single nucleotide polymorphism on all anthropometric values were influenced by the maternal SES, in that a low maternal educational level aggravated the phenotype of adolescents carrying the TT genotype (interactions: P<0.02). No association with EWI-C scores was found, although sweet craving was a more frequent cause of between-meal food intake in TT subjects than in C allele carriers (24.3% vs 9.2%, P=0.01).

Conclusion

In European adolescents, the TT genotype of the NMB rs3809508 polymorphism was associated with a higher risk of obesity. Moreover, the effects of this polymorphism on anthropometric values were influenced by the maternal educational level."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.org/dc/terms/identifier"doi:10.1038/ijo.2009.260"xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Amouyel P."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Pigeyre M."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Gottrand F."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Dallongeville J."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Meirhaeghe A."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Gilbert C.C."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Moreno L.A."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Romon M."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Bokor S."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Gomez-Martinez S."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/author"Valtuena J."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/name"Int J Obes (Lond)"xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/pages"478-486"xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/title"Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study."xsd:string
http://purl.uniprot.org/citations/20010906http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/20010906http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20010906
http://purl.uniprot.org/citations/20010906http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20010906
http://purl.uniprot.org/uniprot/#_P08949-mappedCitation-20010906http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20010906
http://purl.uniprot.org/uniprot/P08949http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20010906