| http://purl.uniprot.org/citations/20017137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20017137 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocellular carcinoma (HCC) is a common cancer, and hepatitis B virus (HBV) is a major etiological agent. Convincing epidemiological and experimental evidence also links HCC to aflatoxin, a naturally occurring mycotoxin that produces a signature p53-249(ser) mutation. Recently, we have reported that tumor-derived HBx variants encoded by HBV exhibited attenuated transactivation and proapoptotic functions but retained their ability to block p53-mediated apoptosis. These results indicate that mutations in HBx may contribute to the development of HCC. In this study, we determined whether tumor-derived HBx mutants along, or in cooperation with p53-249(ser), could alter cell proliferation and chromosome stability of normal human hepatocytes. To test this hypothesis, we established a telomerase immortalized normal human hepatocycte line HHT4 that exhibited a near diploid karyotype and expressed many hepatocyte-specific genes. We found that overexpression one of the tumor-derived HBx mutants, CT, significantly increased colony forming efficiency (CFE) while its corresponding wild-type allele CNT significantly decreased CFE in HHT4 cells. p53-249(ser) rescued CNT-mediated inhibition of colony formation. Although HHT4 cells lacked an anchorage independent growth capability as they did not form any colonies in soft agar, the CT-expressing HHT4 cells could form colonies, which could be significantly enhanced by p53-249(ser). Induction of aneuploidy could be observed in HHT4 cells expressing CT, but additionally recurring chromosome abnormalities could only be detected in cells coexpressing CT and p53-249(ser). Our results are consistent with the hypothesis that certain mutations in HBx and p53 at codon 249 may cooperate in contributing to liver carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.25118"xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Jiang W."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Kim J.W."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Unger T."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Wang X.W."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Harris C.C."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Hussain S.P."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Spillare E.A."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Cavalli L.R."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Haddad B.R."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Bowman E."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Forgues M."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Meck J.M."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/author | "Lipsky M.M."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/pages | "1011-1020"xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/title | "Cooperation of tumor-derived HBx mutants and p53-249(ser) mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line."xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/20017137 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20017137 |
| http://purl.uniprot.org/citations/20017137 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20017137 |
| http://purl.uniprot.org/uniprot/#_A0A0M4B4Y9-mappedCitation-20017137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20017137 |
| http://purl.uniprot.org/uniprot/#_A0A087WXZ1-mappedCitation-20017137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20017137 |