| http://purl.uniprot.org/citations/20017138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20017138 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied orchiectomy specimens from 130 patients immuhistochemically with testicular germ cell tumor (TGCT) using anti-core 2 N-acetylglucosaminyltransferase-1 (C2GnT-1) antibody. The incidence of C2GnT-1 positivity in stage I disease (29.5%, 21/71) was significantly lower than that in higher stages (84.7%, 50/59) (P < 0.001, chi(2) test). This significant difference was also found when the cases were divided into seminoma and NSGCT according to histopathological classification. Kaplan-Meier plots and the log rank test showed that in the patients with stage I seminoma, C2GnT-1-positive cases had a higher risk for recurrence (P < 0.001). This was also the case with the patients with stage I NSGCT (P < 0.001). To determine whether C2GnT-1 promotes aggressive behavior of cancer cells, a C2GnT-1-negative human TGCT cell line, JKT-1, was stably transfected with a mammalian expression vector containing C2GnT-1 cDNA. In vitro assays revealed that JKT-1-C2 cells are more invasive than mock transfectants, although there are no differences in proliferation activity. When orthotopically inoculated into athymic nude mice, JKT-1-C2 cells produced larger testicular tumors extending to the retroperitoneum with mesenteric metastasis, while mock transfectants produced small tumors without metastasis (P < 0.01, Mann-Whitney's U-test). When injected via the tail vein, JKT-1-C2 cells produced a number of metastatic lung foci. In contrast, mock transfectants produced a small number of nodules (p < 0.01, Mann-Whitney's U-test). These results strongly suggest that C2GnT-1 enhances the metastatic potential of TGCT and may be a reliable biomarker for aggressive potential of TGCT."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.25117"xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Arai Y."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Fukuda M."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Hashimoto Y."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Okamoto A."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Yoneyama T."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Yamada S."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Hatakeyama S."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Sugiyama N."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Ohyama C."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Kyan A."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/author | "Koie T."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/pages | "1052-1059"xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/title | "Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumor."xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/20017138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20017138 |
| http://purl.uniprot.org/citations/20017138 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20017138 |
| http://purl.uniprot.org/uniprot/#_B2R8E9-mappedCitation-20017138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20017138 |