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http://purl.uniprot.org/citations/20017310http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20017310http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the association of gene polymorphism of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) with ulcerative colitis (UC) in Chinese.

Methods

One hundred and seventeen patients with UC and 246 healthy controls were genotyped for the polymorphisms of C-658T in the promoter and C61T at the 3' untranslated region of the CTLA-4 gene using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP), respectively. The genotype and allele frequencies of the two groups were calculated and compared by chi square test.

Results

The frequency of TT+CT genotype at the CTLA-4 gene C-658T in the promoter was significantly higher in UC patients than that in healthy controls (P=0.015). The frequency of the T allele at this locus was also significantly higher in UC patients than that in the controls (P=0.033). The frequencies of TT genotype and T allele at the C-658T locus were highly associated with extensive colitis in UC patients (P=0.037, and P=0.0067, respectively).

Conclusion

The T allele of CTLA-4 promoter C-658T locus was highly associated with UC in Chinese Han of central China."xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/author"Jiang T."xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/author"Li C."xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/author"Luo Y."xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/author"Xia B."xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/author"Chen Z.T."xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/author"Ge L.Q."xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/pages"431-434"xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/title"[Association of cytotoxic T lymphocyte antigen-4 promoter C-658T polymorphism with ulcerative colitis in Chinese]."xsd:string
http://purl.uniprot.org/citations/20017310http://purl.uniprot.org/core/volume"26"xsd:string
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