| http://purl.uniprot.org/citations/20018622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20018622 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-4 promotes Th2 differentiation and provides immunity to helminth infections but is also associated with allergy and asthma. This suggests that precise adjustment of IL-4 responsiveness is needed to correctly balance immune responses. The IL-4Ralpha chain is an essential component of the IL-4 receptor and signals via STAT6. In this study, we show that infection with a helminth pathogen elicited broad upregulation of IL-4Ralpha on bystander CD4+ T cells in the draining lymph node, while simultaneously resulting in the loss of IL-4Ralpha expression on activated Th2 cells. IL-4Ralpha upregulation was restricted to the reactive lymph node, occurred within 4 d of infection, and was driven by an IL-4- and STAT6-dependent mechanism. Mice heterozygous for Stat6 exhibited reduced IL-4Ralpha upregulation and a correspondingly attenuated Th2 response. Indeed, the enhanced IL-4Ralpha upregulation in BALB/c mice, compared with that in C57BL6 mice, predicted their stronger Th2 response. The selective downregulation of IL-4Ralpha on highly activated Th cells was triggered by antigenic stimulation, was accompanied by loss of IL-7Ralpha, and rendered the cells unresponsive to IL-4. Together these data reveal a tightly controlled program of changing IL-4 responsiveness that characterizes the initiation, amplification, and restriction of a Th2 response in vivo."xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0902408"xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/author | "Mohrs M."xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/author | "Mohrs K."xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/author | "Mayer K.D."xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/author | "Perona-Wright G."xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/pages | "615-623"xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/title | "Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo."xsd:string |
| http://purl.uniprot.org/citations/20018622 | http://purl.uniprot.org/core/volume | "184"xsd:string |
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