| http://purl.uniprot.org/citations/20018762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20018762 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20018762 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial Ca(2+) efflux is linked to numerous cellular activities and pathophysiological processes. Although it is established that an Na(+)-dependent mechanism mediates mitochondrial Ca(2+) efflux, the molecular identity of this transporter has remained elusive. Here we show that the Na(+)/Ca(2+) exchanger NCLX is enriched in mitochondria, where it is localized to the cristae. Employing Ca(2+) and Na(+) fluorescent imaging, we demonstrate that mitochondrial Na(+)-dependent Ca(2+) efflux is enhanced upon overexpression of NCLX, is reduced by silencing of NCLX expression by siRNA, and is fully rescued by the concomitant expression of heterologous NCLX. NCLX-mediated mitochondrial Ca(2+) transport was inhibited, moreover, by CGP-37157 and exhibited Li(+) dependence, both hallmarks of mitochondrial Na(+)-dependent Ca(2+) efflux. Finally, NCLX-mediated mitochondrial Ca(2+) exchange is blocked in cells expressing a catalytically inactive NCLX mutant. Taken together, our results converge to the conclusion that NCLX is the long-sought mitochondrial Na(+)/Ca(2+) exchanger."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0908099107"xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0908099107"xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Herrmann S."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Herrmann S."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Nolte C."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Nolte C."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Fishman D."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Fishman D."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Sekler I."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Sekler I."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Hershfinkel M."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Hershfinkel M."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Sensi S.L."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Sensi S.L."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Khananshvili D."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Khananshvili D."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Caporale T."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Caporale T."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Palty R."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Palty R."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Parnis J."xsd:string |
| http://purl.uniprot.org/citations/20018762 | http://purl.uniprot.org/core/author | "Parnis J."xsd:string |