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http://purl.uniprot.org/citations/20019330http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20019330http://www.w3.org/2000/01/rdf-schema#comment"

Rationale

Increased sympathetic nerve activity has been linked to the pathogenesis of hypertension in humans and animal models. Enhanced peripheral chemoreceptor sensitivity which increases sympathetic nerve activity has been observed in established hypertension but has not been identified as a possible mechanism for initiating an increase in sympathetic nerve activity before the onset of hypertension.

Objective

We tested this hypothesis by measuring the pH sensitivity of isolated carotid body glomus cells from young spontaneously hypertensive rats (SHR) before the onset of hypertension and their control normotensive Wistar-Kyoto (WKY) rats.

Methods and results

We found a significant increase in the depolarizing effect of low pH in SHR versus WKY glomus cells which was caused by overexpression of 2 acid-sensing non-voltage-gated channels. One is the amiloride-sensitive acid-sensing sodium channel (ASIC3), which is activated by low pH and the other is the 2-pore domain acid-sensing K(+) channel (TASK1), which is inhibited by low pH and blocked by quinidine. Moreover, we found that the increase in sympathetic nerve activity in response to stimulation of chemoreceptors with sodium cyanide was markedly enhanced in the still normotensive young SHR compared to control WKY rats.

Conclusions

Our results establish a novel molecular basis for increased chemotransduction that contributes to excessive sympathetic activity before the onset of hypertension."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.org/dc/terms/identifier"doi:10.1161/circresaha.109.206946"xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/author"Lu Y."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/author"Tan Z.Y."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/author"Paton J.F."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/author"Abboud F.M."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/author"Chapleau M.W."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/author"Whiteis C.A."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/author"Simms A.E."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/name"Circ Res"xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/pages"536-545"xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/title"Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR."xsd:string
http://purl.uniprot.org/citations/20019330http://purl.uniprot.org/core/volume"106"xsd:string
http://purl.uniprot.org/citations/20019330http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20019330
http://purl.uniprot.org/citations/20019330http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20019330
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http://purl.uniprot.org/uniprot/#_A6K563-mappedCitation-20019330http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20019330
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http://purl.uniprot.org/uniprot/#_A6KCG7-mappedCitation-20019330http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20019330
http://purl.uniprot.org/uniprot/#_A6KCG8-mappedCitation-20019330http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20019330
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