| http://purl.uniprot.org/citations/20022898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20022898 | http://www.w3.org/2000/01/rdf-schema#comment | "The mannose-binding lectin gene (MBL-2) has emerged as a candidate for systemic lupus erythematosus susceptibility, but studies in Brazilian population have not been conducted. To examine potential associations of mannose-binding lectin alleles G57E, G54D, IVSnt5, R52C and R52H with susceptibility to and clinical expression of systemic lupus erythematosus in southern Brazilian patients, we conducted a case-control study with 327 consecutive patients with diagnosis of systemic lupus erythematosus and 345 healthy controls. Genotyping was performed by restriction fragment length polymorphism-polymerase chain reaction assay. A statistically significant difference in the frequencies of allele R52C was observed in European-derived systemic lupus erythematosus patients when compared with controls (9.6% vs. 3.3%, p < 0.001, odds ratio: 3.15, 95% confidence interval: 1.76-5.62, p < 0.05). The frequencies of alleles G54D and G57E were not different between European-derived systemic lupus erythematosus patients and controls. There were no differences between clinical and laboratory features in systemic lupus erythematosus patients according to the presence or absence of mannose-binding lectin allelic variants. These results support an increased risk of systemic lupus erythematosus in European-derived individuals carrying allele R52C. Patients carrying this allele have an approximately three-fold higher odds ratio of developing systemic lupus erythematosus when compared with controls. Our data do not support associations between the mannose-binding lectin allelic variants studied and clinical expression of systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.org/dc/terms/identifier | "doi:10.1177/0961203309351895"xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "Xavier R.M."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "Junior J.M."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "Chies J.A."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "Brenol J.C."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "Monticielo O.A."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "Mucenic T."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "Glesse N."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "Rucatti G.G."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "da Silva G.K."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/author | "dos Santos B.P."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/name | "Lupus"xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/pages | "280-287"xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/title | "Mannose-binding lectin gene polymorphisms in Brazilian patients with systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/20022898 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20022898 |
| http://purl.uniprot.org/citations/20022898 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20022898 |
| http://purl.uniprot.org/uniprot/#_P11226-mappedCitation-20022898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20022898 |
| http://purl.uniprot.org/uniprot/#_B1PN75-mappedCitation-20022898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20022898 |
| http://purl.uniprot.org/uniprot/#_Q9HCS8-mappedCitation-20022898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20022898 |
| http://purl.uniprot.org/uniprot/P11226 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20022898 |
| http://purl.uniprot.org/uniprot/Q9HCS8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20022898 |