| http://purl.uniprot.org/citations/20022913 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20022913 | http://www.w3.org/2000/01/rdf-schema#comment | "Humans perceive thousands of compounds as bitter. In sharp contrast, only approximately 25 taste 2 receptors (TAS2R) bitter taste receptors have been identified, raising the question as to how the vast array of bitter compounds can be detected by such a limited number of sensors. To address this issue, we have challenged 25 human taste 2 receptors (hTAS2Rs) with 104 natural or synthetic bitter chemicals in a heterologous expression system. Thirteen cognate bitter compounds for 5 orphan receptors and 64 new compounds for previously identified receptors were discovered. Whereas some receptors recognized only few agonists, others displayed moderate or extreme tuning broadness. Thus, 3 hTAS2Rs together were able to detect approximately 50% of the substances used. Conversely, though 63 bitter substances activated only 1-3 receptors, 19 compounds stimulated up to 15 hTAS2Rs. Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.org/dc/terms/identifier | "doi:10.1093/chemse/bjp092"xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/author | "Kuhn C."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/author | "Meyerhof W."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/author | "Behrens M."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/author | "Bufe B."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/author | "Brockhoff A."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/author | "Appendino G."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/author | "Batram C."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/author | "Chudoba E."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/name | "Chem Senses"xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/pages | "157-170"xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/title | "The molecular receptive ranges of human TAS2R bitter taste receptors."xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/20022913 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20022913 |
| http://purl.uniprot.org/citations/20022913 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20022913 |
| http://purl.uniprot.org/uniprot/P59544#attribution-88B561F5047B2DA76D690D22444DD3A6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20022913 |
| http://purl.uniprot.org/uniprot/P59544#attribution-F3632817D2DD590ECAE5749CB4174805 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20022913 |
| http://purl.uniprot.org/uniprot/Q7RTR8#attribution-F3632817D2DD590ECAE5749CB4174805 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20022913 |
| http://purl.uniprot.org/uniprot/Q9NYW0#attribution-88B561F5047B2DA76D690D22444DD3A6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20022913 |
| http://purl.uniprot.org/uniprot/Q9NYW0#attribution-F3632817D2DD590ECAE5749CB4174805 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20022913 |
| http://purl.uniprot.org/uniprot/P59533#attribution-88B561F5047B2DA76D690D22444DD3A6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20022913 |
| http://purl.uniprot.org/uniprot/P59533#attribution-F3632817D2DD590ECAE5749CB4174805 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20022913 |