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| http://purl.uniprot.org/citations/20023216 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a post-entry CCR6-dependent mechanism of inhibition of HIV occurring at an early stage of infection mediated by the induction of the host restriction factor apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G). We observed induction of APOBEC3G expression only in CCR6(+) cells but not in cells treated with the G inhibitory (Gi) pathway inhibitor pertussis toxin. CCR6 is highly expressed on peripheral blood CD4(+)CCR5(+) memory T cells and by 2 populations of CD4(+) T cells within the gut, alpha4beta7(+) and T helper type 17, that have been implicated in cell-to-cell spread of HIV and enhanced restoration of CD4(+) T cells within gut-associated lymphoid tissue, respectively. This novel CCR6-mediated mechanism of inhibition allows the identification of pathways that induce intrinsic immunity to HIV, which could be useful in devising novel therapeutics that selectively target CCR6(+) cells."xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-06-226423"xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/author | "Lu W."xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/author | "Garzino-Demo A."xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/author | "Lafferty M.K."xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/author | "DeMasi L."xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/pages | "1564-1571"xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/title | "CCR6 ligands inhibit HIV by inducing APOBEC3G."xsd:string |
| http://purl.uniprot.org/citations/20023216 | http://purl.uniprot.org/core/volume | "115"xsd:string |
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