| http://purl.uniprot.org/citations/20026049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20026049 | http://www.w3.org/2000/01/rdf-schema#comment | "Proprotein convertase subtilisin/kexin type 9 (PCSK9), a liver-secreted plasma enzyme, restricts hepatic uptake of low-density lipoprotein (LDL) cholesterol by promoting the degradation of LDL receptors (LDLR). PCSK9 and LDLR are also expressed in insulin-producing pancreatic islet beta cells, possibly affecting the function of these cells. Here we show that, compared to control mice, PCSK9-null male mice over 4 months of age carried more LDLR and less insulin in their pancreas; they were hypoinsulinemic, hyperglycemic and glucose-intolerant; their islets exhibited signs of malformation, apoptosis and inflammation. Collectively, these observations suggest that PCSK9 may be necessary for the normal function of pancreatic islets."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2009.12.018"xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Chen A."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Prat A."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Chretien M."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Mbikay M."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Seidah N.G."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Sirois F."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Mayne J."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Wang G.S."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Dewpura T."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/author | "Scott F.W."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/pages | "701-706"xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/title | "PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities."xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://purl.uniprot.org/core/volume | "584"xsd:string |
| http://purl.uniprot.org/citations/20026049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20026049 |
| http://purl.uniprot.org/citations/20026049 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20026049 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SRE8-mappedCitation-20026049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20026049 |
| http://purl.uniprot.org/uniprot/#_P35951-mappedCitation-20026049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20026049 |
| http://purl.uniprot.org/uniprot/#_Q3U8R7-mappedCitation-20026049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20026049 |
| http://purl.uniprot.org/uniprot/#_Q8CAV5-mappedCitation-20026049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20026049 |
| http://purl.uniprot.org/uniprot/#_P01325-mappedCitation-20026049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20026049 |