http://purl.uniprot.org/citations/20026655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20026655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20026655 | http://www.w3.org/2000/01/rdf-schema#comment | "Knockdown of the actin-severing protein actin-depolymerizing factor (ADF)/cofilin inhibited export of an exogenously expressed soluble secretory protein from Golgi membranes in Drosophila melanogaster and mammalian tissue culture cells. A stable isotope labeling by amino acids in cell culture mass spectrometry-based protein profiling revealed that a large number of endogenous secretory proteins in mammalian cells were not secreted upon ADF/cofilin knockdown. Although many secretory proteins were retained, a Golgi-resident protein and a lysosomal hydrolase were aberrantly secreted upon ADF/cofilin knockdown. Overall, our findings indicate that inactivation of ADF/cofilin perturbed the sorting of a subset of both soluble and integral membrane proteins at the trans-Golgi network (TGN). We suggest that ADF/cofilin-dependent actin trimming generates a sorting domain at the TGN, which filters secretory cargo for export, and that uncontrolled growth of this domain causes missorting of proteins. This type of actin-dependent compartmentalization and filtering of secretory cargo at the TGN by ADF/cofilin could explain sorting of proteins that are destined to the cell surface."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200908040"xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200908040"xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Molina H."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Molina H."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Duran J.M."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Duran J.M."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Malhotra V."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Malhotra V."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Alleaume A.M."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Alleaume A.M."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Egorov M."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Egorov M."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Forlanelli E."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Forlanelli E."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Polishchuk R."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "Polishchuk R."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "von Blume J."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/author | "von Blume J."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
http://purl.uniprot.org/citations/20026655 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |