| http://purl.uniprot.org/citations/20028982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20028982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20028982 | http://www.w3.org/2000/01/rdf-schema#comment | "Fine-tuning of the Wnt/TCF pathway is crucial for multiple embryological processes, including liver development. Here we describe how the interaction between Hhex (hematopoietically expressed homeobox) and SOX13 (SRY-related high mobility group box transcription factor 13), modulates Wnt/TCF pathway activity. Hhex is a homeodomain factor expressed in multiple endoderm-derived tissues, like the liver, where it is essential for proper development. The pleiotropic expression of Hhex during embryonic development and its dual role as a transcriptional repressor and activator suggest the presence of different tissue-specific partners capable of modulating its activity and function. While searching for developmentally regulated Hhex partners, we set up a yeast two-hybrid screening using an E9.5-10.5 mouse embryo library and the N-terminal domain of Hhex as bait. Among the putative protein interactors, we selected SOX13 for further characterization. We found that SOX13 interacts directly with full-length Hhex, and we delineated the interaction domains within the two proteins. SOX13 is known to repress Wnt/TCF signaling by interacting with TCF1. We show that Hhex is able to block the SOX13-dependent repression of Wnt/TCF activity by displacing SOX13 from the SOX13 x TCF1 complex. Moreover, Hhex de-repressed the Wnt/TCF pathway in the ventral foregut endoderm of cultured mouse embryos electroporated with a SOX13-expressing plasmid. We conclude that the interaction between Hhex and SOX13 may contribute to control Wnt/TCF signaling in the early embryo."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.046649"xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.046649"xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Pierreux C.E."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Pierreux C.E."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Castell J.V."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Castell J.V."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Moya M."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Moya M."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Real F.X."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Real F.X."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Bort R."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Bort R."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Lemaigre F.P."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Lemaigre F.P."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Marfil V."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/author | "Marfil V."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/pages | "5726-5737"xsd:string |
| http://purl.uniprot.org/citations/20028982 | http://purl.uniprot.org/core/pages | "5726-5737"xsd:string |