| http://purl.uniprot.org/citations/20028983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20028983 | http://www.w3.org/2000/01/rdf-schema#comment | "Beta2-microglobulin (beta2m), the light chain of class I major histocompatibility complex, is responsible for the dialysis-related amyloidosis and, in patients undergoing long term dialysis, the full-length and chemically unmodified beta2m converts into amyloid fibrils. The protein, belonging to the immunoglobulin superfamily, in common to other members of this family, experiences during its folding a long-lived intermediate associated to the trans-to-cis isomerization of Pro-32 that has been addressed as the precursor of the amyloid fibril formation. In this respect, previous studies on the W60G beta2m mutant, showing that the lack of Trp-60 prevents fibril formation in mild aggregating condition, prompted us to reinvestigate the refolding kinetics of wild type and W60G beta2m at atomic resolution by real-time NMR. The analysis, conducted at ambient temperature by the band selective flip angle short transient real-time two-dimensional NMR techniques and probing the beta2m states every 15 s, revealed a more complex folding energy landscape than previously reported for wild type beta2m, involving more than a single intermediate species, and shedding new light into the fibrillogenic pathway. Moreover, a significant difference in the kinetic scheme previously characterized by optical spectroscopic methods was discovered for the W60G beta2m mutant."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.061168"xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Corazza A."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Esposito G."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Viglino P."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Bellotti V."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Schanda P."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Brutscher B."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Gal M."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Fogolari F."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Giorgetti S."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Mimmi M.C."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Raimondi S."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Rennella E."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Cutuil T."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/author | "Frydman L."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/pages | "5827-5835"xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/title | "Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR."xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20028983 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20028983 |
| http://purl.uniprot.org/citations/20028983 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20028983 |
| http://purl.uniprot.org/uniprot/#_P61769-mappedCitation-20028983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20028983 |