| http://purl.uniprot.org/citations/20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20033059 | http://www.w3.org/2000/01/rdf-schema#comment | "The chaperone Hsc70 drives the clathrin assembly-disassembly cycle forward by stimulating dissociation of a clathrin lattice. A J-domain containing co-chaperone, auxilin, associates with a freshly budded clathrin-coated vesicle, or with an in vitro assembled clathrin coat, and recruits Hsc70 to its specific heavy-chain-binding site. We have determined by electron cryomicroscopy (cryoEM), at about 11 A resolution, the structure of a clathrin coat (in the D6-barrel form) with specifically bound Hsc70 and auxilin. The Hsc70 binds a previously analysed site near the C-terminus of the heavy chain, with a stoichiometry of about one per three-fold vertex. Its binding is accompanied by a distortion of the clathrin lattice, detected by a change in the axial ratio of the D6 barrel. We propose that when Hsc70, recruited to a position close to its target by the auxilin J-domain, splits ATP, it clamps firmly onto its heavy-chain site and locks in place a transient fluctuation. Accumulation of the local strain thus imposed at multiple vertices can then lead to disassembly."xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.383"xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/author | "Xing Y."xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/author | "Grigorieff N."xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/author | "Harrison S.C."xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/author | "Kirchhausen T."xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/author | "Wolf M."xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/author | "Bocking T."xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/pages | "655-665"xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/title | "Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly."xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20033059 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20033059 |
| http://purl.uniprot.org/citations/20033059 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20033059 |
| http://purl.uniprot.org/uniprot/#_P11142-mappedCitation-20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20033059 |
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| http://purl.uniprot.org/uniprot/#_P63027-mappedCitation-20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20033059 |
| http://purl.uniprot.org/uniprot/#_Q14247-mappedCitation-20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20033059 |
| http://purl.uniprot.org/uniprot/#_Q15642-mappedCitation-20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20033059 |
| http://purl.uniprot.org/uniprot/#_O15144-mappedCitation-20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20033059 |
| http://purl.uniprot.org/uniprot/#_O15145-mappedCitation-20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20033059 |
| http://purl.uniprot.org/uniprot/#_P01130-mappedCitation-20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20033059 |
| http://purl.uniprot.org/uniprot/#_P01133-mappedCitation-20033059 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20033059 |