| http://purl.uniprot.org/citations/20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20036725 | http://www.w3.org/2000/01/rdf-schema#comment | "Aging is a complex process accompanied by a decreased capacity to tolerate and respond to various stresses. Heat shock proteins as part of cell defense mechanisms are up-regulated following stress. In Drosophila, the mitochondrial Hsp22 is preferentially up-regulated in aged flies. Its over-expression results in an extension of lifespan and an increased resistance to stress. Hsp22 has chaperone-like activity in vitro, but the mechanism(s) by which it increases lifespan in flies are unknown. Genome-wide analysis was performed on long-lived Hsp22+ and control flies to unveil transcriptional changes brought by Hsp22. Transcriptomes obtained at 45days, 90% and 50% survival were then compared between them to focus more on genes up- or down-regulated in presence of higher levels of hsp22 mRNA. Hsp22+ flies display an up-regulation of genes mainly related to mitochondrial energy production and protein biosynthesis, two functions normally down-regulated during aging. Interestingly, among the 26 genes up-regulated in Hsp22+ flies, 7 genes encode for mitochondrial proteins, 5 of which being involved in OXPHOS complexes. Other genes that could influence aging such as CG5002, dGCC185 and GstS1 also displayed a regulation linked to Hsp22 expression. The up-regulation of genes of the OXPHOS system in Hsp22+ flies suggest that mitochondrial homeostasis is at the center of Hsp22 beneficial effects on lifespan."xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exger.2009.12.012"xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/author | "Tanguay R.M."xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/author | "Michaud S."xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/author | "Morrow G."xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/author | "Westwood J.T."xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/name | "Exp Gerontol"xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/pages | "611-620"xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/title | "Gene expression profiling implicates OXPHOS complexes in lifespan extension of flies over-expressing a small mitochondrial chaperone, Hsp22."xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/20036725 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20036725 |
| http://purl.uniprot.org/citations/20036725 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20036725 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFT5-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEQ9-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFL3-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |
| http://purl.uniprot.org/uniprot/#_A0A0S0WNI0-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |
| http://purl.uniprot.org/uniprot/#_E1JGT3-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |
| http://purl.uniprot.org/uniprot/#_E1JGZ3-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LHL7-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |
| http://purl.uniprot.org/uniprot/#_A0A6M3Q7S1-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4LGE6-mappedCitation-20036725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20036725 |