| http://purl.uniprot.org/citations/20038680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20038680 | http://www.w3.org/2000/01/rdf-schema#comment | "Intracellular transport is typically bidirectional, consisting of a series of back and forth movements. Kinesin-1 and cytoplasmic dynein require each other for bidirectional transport of intracellular cargo along microtubules; i.e., inhibition or depletion of kinesin-1 abolishes dynein-driven cargo transport and vice versa. Using Drosophila melanogaster S2 cells, we demonstrate that replacement of endogenous kinesin-1 or dynein with an unrelated, peroxisome-targeted motor of the same directionality activates peroxisome transport in the opposite direction. However, motility-deficient versions of motors, which retain the ability to bind microtubules and hydrolyze adenosine triphosphate, do not activate peroxisome motility. Thus, any pair of opposite-polarity motors, provided they move along microtubules, can activate one another. These results demonstrate that mechanical interactions between opposite-polarity motors are necessary and sufficient for bidirectional organelle transport in live cells."xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200908075"xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/author | "Gelfand V.I."xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/author | "Rice S.E."xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/author | "Ally S."xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/author | "Larson A.G."xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/author | "Barlan K."xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/pages | "1071-1082"xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/title | "Opposite-polarity motors activate one another to trigger cargo transport in live cells."xsd:string |
| http://purl.uniprot.org/citations/20038680 | http://purl.uniprot.org/core/volume | "187"xsd:string |
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