| http://purl.uniprot.org/citations/20040767 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20040767 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly) in DARC, the gene for Duffy antigen receptor for chemokines, a known vascular reservoir of proinflammatory cytokines (minor allele frequency, 45.6%; P < 1.0 * 10(-323)). This association was supported by family-based genetic linkage at a locus encompassing the DARC gene (genome-wide P = 8.0 * 10(-13)). Asp42Gly accounted for approximately 20% of the variability in serum MCP-1 concentrations and also was associated with serum concentrations of interleukin-8 and RANTES. While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (P = .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc. Quantitative immunoflow cytometry failed to identify meaningful Asp42Gly-associated differences in Darc expression, suggesting that a functional change is responsible for the differential cytokine binding. We conclude that Asp42Gly is a major regulator of erythrocyte Darc-mediated cytokine binding and thereby the circulating concentrations of several proinflammatory cytokines. We have also identified for the first time 2 mechanisms for the release of reservoir chemokines with possible clinical implications."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-05-221382"xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Koenig W."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Dupuis J."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Benjamin E.J."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Boerwinkle E."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Dehghan A."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Witteman J.C."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Peters A."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Gieger C."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Illig T."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Ballantyne C.M."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Barbalic M."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Bis J.C."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Psaty B.M."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Ellinor P.T."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Blankenberg S."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Larson M.G."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Doyle M."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Klopp N."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Baumert J."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Keaney J.F. Jr."xsd:string |
| http://purl.uniprot.org/citations/20040767 | http://purl.uniprot.org/core/author | "Tilley C."xsd:string |