| http://purl.uniprot.org/citations/20041275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20041275 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20041275 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of three isoforms of protein kinase CK1 (alpha, gamma(1), and delta) to phosphorylate the N-terminal region of p53 has been assessed using either recombinant p53 or a synthetic peptide reproducing its 1-28 sequence. Both substrates are readily phosphoylated by CK1delta and CK1alpha, but not by the gamma isoform. Affinity of full size p53 for CK1 is 3 orders of magnitude higher than that of its N-terminal peptide (K (m) 0.82 muM vs 1.51 mM). The preferred target is S20, whose phosphorylation critically relies on E17, while S6 is unaffected despite displaying the same consensus (E-x-x-S). Our data support the concept that non-primed phosphorylation of p53 by CK1 is an isoform-specific reaction preferentially affecting S20 by a mechanism which is grounded both on a local consensus and on a remote docking site mapped to the K(221)RQK(224) loop according to modeling and mutational analysis."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-009-0236-7"xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-009-0236-7"xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Pinna L.A."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Pinna L.A."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Marin O."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Marin O."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Sarno S."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Sarno S."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Cozza G."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Cozza G."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Bustos V.H."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Bustos V.H."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Venerando A."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/author | "Venerando A."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/name | "Cell. Mol. Life Sci."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/name | "Cell. Mol. Life Sci."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/pages | "1105-1118"xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/pages | "1105-1118"xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/title | "Isoform specific phosphorylation of p53 by protein kinase CK1."xsd:string |
| http://purl.uniprot.org/citations/20041275 | http://purl.uniprot.org/core/title | "Isoform specific phosphorylation of p53 by protein kinase CK1."xsd:string |