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http://purl.uniprot.org/citations/20042118http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20042118http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20042118http://www.w3.org/2000/01/rdf-schema#comment"

Background

During development, different signaling pathways interact to specify cell fate by regulating transcription factors necessary for fate specification and morphogenesis. In Caenorhabditis elegans, the EGF-Ras and Wnt signaling pathways have been shown to interact to specify cell fate in three equivalence groups: the vulval precursor cells (VPCs), the hook competence group (HCG) and P11/12. In the VPCs, HCG and P11/12 pair, EGF and Wnt signaling positively regulate different Hox genes, each of which also functions during fate specification. In the male, EGF-Ras signaling is required to specify the Bgamma fate within the Bgamma/delta equivalence pair, while Notch signaling is required for Bdelta fate specification. In addition, TGF-beta signaling by dbl-1/dpp controls ceh-13/labial/Hox1 expression in Bgamma.

Results

We show that EGF-Ras signaling is required for Bgamma expression of ceh-13/labial/Hox1. The transcription factors lin-1/ETS and lin-31/Forkhead, functioning downstream of the EGF pathway, as well as sur-2/MED23 (a component of the Mediator complex) also control ceh-13 expression in Bgamma. In addition, our results indicate that lin-44/Wnt, mom-2/Wnt and lin-17/Fz are necessary to maintain the division of Bgamma along a longitudinal axis. We also show that dbl-1/dpp acts either in parallel or downstream of EGF pathway to regulate ceh-13/Hox1 expression in Bgamma. Lastly, we find that a dbl-1/dpp null mutation did not cause any vulval or P12 defects and did not enhance vulval and P12 defects of reduction-of-function mutations of components of the EGF pathway.

Conclusions

ceh-13/labial/Hox1 expression in Bgamma is regulated by the EGF pathway and downstream factors lin-1/ETS lin-31/Forkhead and sur-2/MED23. Wnt signaling is required for proper Bgamma division, perhaps to orient the Bgamma mitotic spindle. Our results suggest that dbl-1/dpp is not required for VPC and P12 specification, highlighting another difference among these EGF-dependent equivalence groups."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.org/dc/terms/identifier"doi:10.1186/1471-213x-9-74"xsd:string
http://purl.uniprot.org/citations/20042118http://purl.org/dc/terms/identifier"doi:10.1186/1471-213x-9-74"xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/author"Sternberg P.W."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/author"Sternberg P.W."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/author"Seah A."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/author"Seah A."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/name"BMC Dev. Biol."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/name"BMC Dev. Biol."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/pages"74"xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/pages"74"xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/title"The roles of EGF and Wnt signaling during patterning of the C. elegans Bgamma/delta Equivalence Group."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/title"The roles of EGF and Wnt signaling during patterning of the C. elegans Bgamma/delta Equivalence Group."xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/20042118http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/20042118http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20042118
http://purl.uniprot.org/citations/20042118http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20042118
http://purl.uniprot.org/citations/20042118http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20042118
http://purl.uniprot.org/citations/20042118http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20042118
http://purl.uniprot.org/uniprot/Q27886http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/20042118
http://purl.uniprot.org/uniprot/Q27886#attribution-5B3B62F6274242F71A5B990F3FFB74E9http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/20042118
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